Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia.

ABSTRACT:

Background/aims

Understanding leukemic stem cell (LSC) is important for acute myeloid leukemia (AML) treatment. However, association of LSC with patient prognosis and genetic information in AML patients is unclear.

Methods

Here we investigated the associations between genetic information and the various LSC phenotypes, namely multipotent progenitor (MPP)-like, lymphoid primed multipotent progenitor (LMPP)-like and granulocyte-macrophage progenitors (GMP)-like LSC in 52 AML patients.

Results

In secondary AML patients, MPP-like LSC was significantly higher than de novo AML (p = 0.0037). The proportion of MPP-like LSC was especially high in post-myeloproliferative neoplasm AML (p = 0.0485). There was no correlation between age and LSC phenotype. Mutations of KRAS and NRA

SUBMITTER: Han H 

PROVIDER: S-EPMC7969060 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature