Efficacy of prehospital administration of fibrinogen concentrate in trauma patients bleeding or presumed to bleed (FIinTIC): A multicentre, double-blind, placebo-controlled, randomised pilot study.

ABSTRACT:

Background

Trauma-induced coagulopathy (TIC) substantially contributes to mortality in bleeding trauma patients.

Objective

The aim of the study was to administer fibrinogen concentrate in the prehospital setting to improve blood clot stability in trauma patients bleeding or presumed to bleed.

Design

A prospective, randomised, placebo-controlled, double-blinded, international clinical trial.

Setting

This emergency care trial was conducted in 12 Helicopter Emergency Medical Services (HEMS) and Emergency Doctors' vehicles (NEF or NAW) and four trauma centres in Austria, Germany and Czech Republic between 2011 and 2015.

Patients

A total of 53 evaluable trauma patients aged at least 18 years with major bleeding and in need of volume therapy were included, of

SUBMITTER: Ziegler B 

PROVIDER: S-EPMC7969176 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature