Emergency administration of fibrinogen concentrate for hemorrhage: A protocol for systematic review and meta-analysis.

ABSTRACT:

Introduction

The occurrence of massive hemorrhages in various emergency situations increases the need for blood transfusions and the risk of mortality. Use of fibrinogen concentrate (FC) may increase plasma fibrinogen levels more rapidly than the use of fresh-frozen product or cryoprecipitate. However, thus far, the efficacy of FC in significantly improving the risk of mortality and significantly reducing transfusion requirements has not been effectively demonstrated in several systematic reviews and meta-analyses.

Methods and analysis

We will conduct a systematic review and meta-analysis of FC for hemorrhages in emergency situations. We will include controlled trials, but will exclude randomized controlled trials in elective surgeries. We will include patients with hemorrha

SUBMITTER: Itagaki Y 

PROVIDER: S-EPMC7969309 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature