IgA transcytosis and antigen recognition govern ovarian cancer immunity.

ABSTRACT: Most ovarian cancers are infiltrated by prognostically relevant activated T cells^1-3, yet exhibit low response rates to immune checkpoint inhibitors⁴. Memory B cell and plasma cell infiltrates have previously been associated with better outcomes in ovarian cancer^5,6, but the nature and functional relevance of these responses are controversial. Here, using 3 independent cohorts that in total comprise 534 patients with high-grade serous ovarian cancer, we show that robust, protective humoral responses are dominated by the production of polyclonal IgA, which binds to polymeric IgA receptors that are universally expressed on ovarian cancer cells. Notably, tumour B-cell-derived IgA redirects myeloid cells against extracellular oncogenic drivers, which causes tum

SUBMITTER: Biswas S 

PROVIDER: S-EPMC7969354 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature