Sulfur sequestration promotes multicellularity during nutrient limitation.

ABSTRACT: The behaviour of Dictyostelium discoideum depends on nutrients¹. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism^2,3. This biology makes D. discoideum an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species-generated as a consequence of nutrient limitation-lead to the sequestration of cysteine in the antioxidant glutathione. This sequestration limits the use of the sulfur atom of cysteine in processes that contribute to mitochondrial metabolism and cellular proliferation, such as protein translation and the activity of enzymes that contain an iron-sulfur cluster. The regulated sequestratio

SUBMITTER: Kelly B 

PROVIDER: S-EPMC7969356 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature