Hydrogen Sulfide Oxidation by Sulfide Quinone Oxidoreductase.

ABSTRACT: Hydrogen sulfide (H₂ S) is an environmental toxin and a heritage of ancient microbial metabolism that has stimulated new interest following its discovery as a neuromodulator. While many physiological responses have been attributed to low H₂ S levels, higher levels inhibit complex IV in the electron transport chain. To prevent respiratory poisoning, a dedicated set of enzymes that make up the mitochondrial sulfide oxidation pathway exists to clear H₂ S. The committed step in this pathway is catalyzed by sulfide quinone oxidoreductase (SQOR), which couples sulfide oxidation to coenzyme Q₁₀ reduction in the electron transport chain. The SQOR reaction prevents H₂ S accumulation and generates highly reactive persulfide species as products;

SUBMITTER: Landry AP 

PROVIDER: S-EPMC7969369 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature