Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model.

ABSTRACT: Lung cancer is the leading cause of cancer-related death globally. An improved risk stratification strategy can increase efficiency of low-dose CT (LDCT) screening. Here we assessed whether individual's genetic background has clinical utility for risk stratification in the context of LDCT screening. On the basis of 13,119 patients with lung cancer and 10,008 controls with European ancestry in the International Lung Cancer Consortium, we constructed a polygenic risk score (PRS) via 10-fold cross-validation with regularized penalized regression. The performance of risk model integrating PRS, including calibration and ability to discriminate, was assessed using UK Biobank data (N = 335,931). Absolute risk was estimated on the basis of age-specific lung cancer incidence and all-cause mo

SUBMITTER: Hung RJ 

PROVIDER: S-EPMC7969419 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature