Molecular Mechanisms of Adenosine Stress T1 Mapping.

ABSTRACT:

Background

Adenosine stress T1 mapping is an emerging magnetic resonance imaging method to investigate coronary vascular function and myocardial ischemia without application of a contrast agent. Using gene-modified mice and 2 vasodilators, we elucidated and compared the mechanisms of adenosine myocardial perfusion imaging and adenosine T1 mapping.

Methods

Wild-type (WT), A_2AAR^-/- (adenosine A_2A receptor knockout), A_2BAR^-/- (adenosine A_2B receptor knockout), A₃AR^-/- (adenosine A₃ receptor knockout), and eNOS^-/- (endothelial nitric oxide synthase knockout) mice underwent rest and stress perfusion magnetic resonance imaging (n=8) and T1 mapping (n=10) using either adeno

SUBMITTER: Shah SA 

PROVIDER: S-EPMC7969455 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature