C20orf204, a hepatocellular carcinoma-specific protein interacts with nucleolin and promotes cell proliferation.

ABSTRACT: In most human cancers, a large number of proteins with driver mutations are involved in tumor development, implying that multiple fine tuners are involved in cancer formation and/or maintenance. A useful strategy for cancer therapy may therefore be to target multiple cancer type-specific fine tuners. Furthermore, genome-wide association studies of tumor samples have identified a large number of long noncoding (lnc)RNA associated with various types of tumor. In this context we have previously found that C20orf204 (a splice variant of Linc00176) RNA contains a 189 amino acid (AA) long open reading frame (C20orf204-189AA) that is expressed predominantly in hepatocellular carcinoma (HCC). We report here that a protein, C20orf204-189AA, was detected in the nucleus of 14 out of 20 primary HCC, b

SUBMITTER: Burbano De Lara S 

PROVIDER: S-EPMC7969625 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature