Systematic Assessment of Safety Threshold for Donor Age in Cadaveric Liver Transplantation.

ABSTRACT: Background: Donor age affects allograft quality and the prognosis of recipients after liver transplantation (LT). Clinicians have assessed the quality of grafts from older donors based on their appearance and texture, with no reliable quantitative evidence. Our study aimed to assess the quantitative impact of donor age on post-transplant outcomes and its safety threshold for LT, based on the published literature. Methods: Relevant studies were retrieved from the Embase, PubMed, and ISI Web of Science databases. Pooled dichotomous relative risks (RRs) were calculated using metan. Continuous RRs were calculated using a two-stage random-effects model. Results: Eleven studies including 30,691 LT cases were included for further analysis. For categorical comparison, the RR o

SUBMITTER: Wang W 

PROVIDER: S-EPMC7969668 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature