Autoradiographical assessment of inflammation-targeting radioligands for atherosclerosis imaging: potential for plaque phenotype identification.

ABSTRACT:

Purpose

Many radioligands have been developed for the visualization of atherosclerosis by targeting inflammation. However, interpretation of in vivo signals is often limited to plaque identification. We evaluated binding of some promising radioligands in an in vitro approach in atherosclerotic plaques with different phenotypes.

Methods

Tissue sections of carotid endarterectomy tissue were characterized as early plaque, fibro-calcific plaque, or phenotypically vulnerable plaque. In vitro binding assays for the radioligands [¹¹¹In]In-DOTATATE; [¹¹¹In]In-DOTA-JR11; [⁶⁷Ga]Ga-Pentixafor; [¹¹¹In]In-DANBIRT; and [¹¹¹In]In-EC0800 were conducted, the expression of the radioligand targets was assessed via immunohistochemistry. Rad

SUBMITTER: Meester EJ 

PROVIDER: S-EPMC7969682 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature