Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice.

ABSTRACT: Gut microbiota regulate the neurodevelopmental processes and brain functions through the regulation of the microbiota-gut interaction and gut-brain communication. Buspirone, an agonist for serotonin 5-HT1A receptors, is used for the treatment of anxiety/depression. Therefore, to understand the gut microbiota-mediated mechanism of buspirone on anxiety/depression, we examined its effect on the immobilization stress (IS) or Escherichia coli K1 (EC)-induced anxiety/depression in mice. Oral or intraperitoneal administration of buspirone significantly suppressed stressor-induced anxiety/depression-like behaviors in the elevated plus maze, light/dark transition, tail suspension, and forced swimming tasks. Their treatments also reduced TNF-α expression and NF-κB⁺/Iba1⁺ cell p

SUBMITTER: Kim JK 

PROVIDER: S-EPMC7969772 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature