2D MXenes with antiviral and immunomodulatory properties: A pilot study against SARS-CoV-2.

ABSTRACT: Two-dimensional transition metal carbides/carbonitrides known as MXenes are rapidly growing as multimodal nanoplatforms in biomedicine. Here, taking SARS-CoV-2 as a model, we explored the antiviral properties and immune-profile of a large panel of four highly stable and well-characterized MXenes - Ti₃C₂T_x, Ta₄C₃T _x , Mo₂Ti₂C₃T _x and Nb₄C₃T _x . To start with antiviral assessment, we first selected and deeply analyzed four different SARS-CoV-2 genotypes, common in most countries and carrying the wild type or mutated spike protein. When inhibition of the viral infection was tested in vitro with four viral clades, Ti₃C

SUBMITTER: Unal MA 

PROVIDER: S-EPMC7969865 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature