Identification of Five Glycolysis-Related Gene Signature and Risk Score Model for Colorectal Cancer.

ABSTRACT: Metabolic changes, especially in glucose metabolism, are widely established during the occurrence and development of tumors and regarded as biological markers of pan-cancer. The well-known 'Warburg effect' demonstrates that cancer cells prefer aerobic glycolysis even if there is sufficient ambient oxygen. Accumulating evidence suggests that aerobic glycolysis plays a pivotal role in colorectal cancer (CRC) development. However, few studies have examined the relationship of glycolytic gene clusters with prognosis of CRC patients. Here, our aim is to build a glycolysis-associated gene signature as a biomarker for colorectal cancer. The mRNA sequencing and corresponding clinical data were downloaded from TCGA and GEO databases. Gene set enrichment analysis (GSEA) was performed, indicating tha

SUBMITTER: Zhu J 

PROVIDER: S-EPMC7969881 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature