Iron Status May Not Affect Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies have shown an association of increased iron status with a higher risk of amyotrophic lateral sclerosis (ALS). Iron status might be a novel target for ALS prevention if a causal relationship exists. We aimed to reveal the causality between iron status and ALS incidence using a large two-sample Mendelian randomization (MR).

Methods

Single nucleotide polymorphisms (SNPs) for iron status were identified from a genome-wide association study (GWAS) on 48,972 individuals. The outcome data came from the largest ALS GWAS to date (20,806 cases; 59,804 controls). We conducted conservative analyses (using SNPs with concordant change of biomarkers of iron status) and liberal analyses (using SNPs associated with at least one of the biomarkers of iron statu

SUBMITTER: Cai J 

PROVIDER: S-EPMC7969891 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature