Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.

ABSTRACT: Anomalous patterns of brain gyrification have been reported in major psychiatric disorders, presumably reflecting their neurodevelopmental pathology. However, previous reports presented conflicting results of patients having hyper-, hypo-, or normal gyrification patterns and lacking in transdiagnostic consideration. In this article, we systematically review previous magnetic resonance imaging studies of brain gyrification in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder at varying illness stages, highlighting the gyral pattern trajectory for each disorder. Patients with each psychiatric disorder may exhibit deviated primary gyri formation under neurodevelopmental genetic control in their fetal life and infancy, and then exhibit higher-order gyral

SUBMITTER: Sasabayashi D 

PROVIDER: S-EPMC7969935 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature