Effect of memantine, an anti-Alzheimer's drug, on rodent microglial cells in vitro.

ABSTRACT: The pathophysiology of Alzheimer's disease (AD) is related to neuroinflammatory responses mediated by microglia. Memantine, an antagonist of N-methyl-D-aspartate (NMDA) receptors used as an anti-Alzheimer's drug, protects from neuronal death accompanied by suppression of proliferation and activation of microglial cells in animal models of AD. However, it remains to be tested whether memantine can directly affect microglial cell function. In this study, we examined whether pretreatment with memantine affects intracellular NO and Ca²⁺ mobilization using DAF-2 and Fura-2 imaging, respectively, and tested the effects of memantine on phagocytic activity by human β-Amyloid (1-42) phagocytosis assay in rodent microglial cells. Pretreatment with memantine did not affect production of NO

SUBMITTER: Murakawa-Hirachi T 

PROVIDER: S-EPMC7969939 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature