Vaginal microbiome and serum metabolite differences in late gestation commercial sows at risk for pelvic organ prolapse.

ABSTRACT: Sow mortality attributable to pelvic organ prolapse (POP) has increased in the U.S. swine industry and continues to worsen. Two main objectives of this study were, (1) to develop a perineal scoring system that can be correlated with POP risk, and (2) identify POP risk-associated biological factors. To assess POP risk during late gestation, sows (n = 213) were scored using a newly developed perineal scoring (PS) system. Sows scored as PS1 (low), PS2 (moderate), or PS3 (high) based on POP risk. Subsequently, 1.5, 0.8, and 23.1% of sows scored PS1, PS2, or PS3, respectively, experienced POP. To identify biomarkers, serum and vaginal swabs were collected from late gestation sows differing in PS. Using GC-MS, 82 serum metabolite differences between PS1 and PS3 animals (P < 0.05) were identified

SUBMITTER: Kiefer ZE 

PROVIDER: S-EPMC7969946 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature