RNA-Seq Analysis Reveals the Role of Omp16 in Brucella-Infected RAW264.7 Cells.

ABSTRACT: Brucellosis is an endemic zoonotic infectious disease in the majority of developing countries, which causes huge economic losses. As immunogenic and protective antigens at the surface of Brucella spp., outer membrane proteins (Omps) are particularly attractive for developing vaccine and could have more relevant role in host-pathogen interactions. Omp16, a homolog to peptidoglycan-associated lipoproteins (Pals), is essential for Brucella survival in vitro. At present, the functions of Omp16 have been poorly studied. Here, the gene expression profile of RAW264.7 cells infected with Brucella suis vaccine strain 2 (B. suis S2) and ΔOmp16 was analyzed by RNA-seq to investigate the cellular response immediately after Brucella entry. The RNA-sequence anal

SUBMITTER: Zhou D 

PROVIDER: S-EPMC7970042 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature