Effect of remote ischaemic preconditioning on mortality and morbidity after non-cardiac surgery: meta-analysis.

ABSTRACT: Remote ischaemic preconditioning (RIPC) has been shown to have a protective role on vital organs exposed to reperfusion injury. The aim of this systematic review was to evaluate the effects of non-invasive RIPC on clinical and biochemical outcomes in patients undergoing non-cardiac surgery. A systematic literature search of PubMed, EMBASE, Scopus, and Cochrane databases was carried out in February 2020. RCTs investigating the effect of non-invasive RIPC in adults undergoing non-cardiac surgery were included. Meta-analyses and trial sequential analyses (TSAs) were performed on cardiovascular events, acute kidney injury, and short- and long-term mortality. Some 43 RCTs including 3660 patients were included. The surgical areas comprised orthopaedic, vascular, abdominal, pulmonary, neurologica

SUBMITTER: Wahlstrom KL 

PROVIDER: S-EPMC7970092 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature