Association between GPER gene polymorphisms and GPER expression levels with cancer predisposition and progression.

ABSTRACT: Estrogen is a female sex steroid hormone that plays a significant role in physiological functions. Evidence suggests that estrogen-signaling pathways are closely linked to cancer development and progression. The novel G protein-coupled estrogen receptor (GPER or GPR30) has been shown to influence cancer predisposition and progression, although results of related studies remain equivocal. Thus, this meta-analysis aimed to estimate the relationship between GPER gene polymorphisms and GPER expression levels, with cancer predisposition and progression. The pooled results showed that two GPER polymorphisms, rs3808350 and rs3808351, were significantly associated with cancer predisposition, especially in the Asian population, but no significant association was detected for rs1154433

SUBMITTER: Ulhaq ZS 

PROVIDER: S-EPMC7970143 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature