SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis.

ABSTRACT: Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form new blood vessels from preexisting vascular beds. This process is tightly regulated by pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which promote signaling pathways involving the increase in the intracellular Ca²⁺ concentration ([Ca²⁺]_i). Recent evidence suggests that store-operated calcium entry (SOCE) might play a role in angiogenesis. However, little is known regarding the role of SARAF, SOCE-associated regulatory factor, and Orai1, the pore-forming subunit of the store-operated calcium channel (SOCC), in angiogenesis. Here, we show that SOCE inhibition with GSK-7975A blocks aorta sprouting, as well as human umbilical vein endotheli

SUBMITTER: Galeano-Otero I 

PROVIDER: S-EPMC7970240 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature