Dose-response meta-analysis of arsenic exposure in drinking water and hypertension.

ABSTRACT:

Background

Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension.

Methods

We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n = 28255) that report Odds Ratio for hypertension. The extracted ORs between As concentration and hypertension were pooled using random effect models. Study heterogeneity was analyzed using I ².

Results

The estimated adjusted OR for association between As and hypertension was 1.44 (95% CI: 1.12, 1.84) with I ² = 71%. Dose-Response analysis showed a linear relationship between As and hypertension (OR = 1.0008 95% CI: 1.0003, 1.001). In general, by increase of each

SUBMITTER: Amiri A 

PROVIDER: S-EPMC7970273 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature