Association of Potent and Very Potent Topical Corticosteroids and the Risk of Osteoporosis and Major Osteoporotic Fractures.

ABSTRACT:

Importance

Systemic and inhaled corticosteroids negatively affect bone remodeling and cause osteoporosis and bone fracture when given continuously or in high doses. However, risk of osteoporosis and major osteoporotic fracture (MOF) after application of topical corticosteroids (TCSs) is largely unexplored.

Objective

To examine the association between cumulative exposure to potent and very potent TCSs and risk of osteoporosis and MOF.

Design, setting, and participants

This nationwide retrospective cohort study included 723 251 Danish adults treated with potent or very potent TCSs from January 1, 2003, to December 31, 2017. Data were obtained from Danish nationwide registries. Filled prescription data were converted in equipotent doses to mometasone furoate (1 mg/g). Da

SUBMITTER: Egeberg A 

PROVIDER: S-EPMC7970335 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature