Cerebral Blood Flow Is Associated with Diagnostic Class and Cognitive Decline in Alzheimer's Disease.

ABSTRACT:

Background

Reliable cerebral blood flow (CBF) biomarkers using a noninvasive imaging technique are sought to facilitate early diagnosis and intervention in early Alzheimer's disease (AD).

Objective

We aim to identify brain regions in which CBF values are affected and related to cognitive decline in early AD using a large cohort.

Methods

Perfusion MRIs using continuous arterial spin labeling were acquired at 1.5 T in 58 normal controls (NC), 50 mild cognitive impairments (MCI), and 40 AD subjects from the Cardiovascular Health Study Cognition Study. Regional absolute CBF and normalized CBF (nCBF) values, without and with correction of partial volume effects, were compared across three groups. Association between regional CBF values and Modified Mini-Mental State Examin

SUBMITTER: Duan W 

PROVIDER: S-EPMC7970411 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature