Effects of administration route on uptake kinetics of ¹⁸F-sodium fluoride positron emission tomography in mice.

ABSTRACT: ¹⁸F-sodium fluoride (¹⁸F-NaF) is a positron emission tomography (PET) radiotracer widely used in skeletal imaging and has also been proposed as a biomarker of active calcification in atherosclerosis. Like most PET radiotracers, ¹⁸F-NaF is typically administered intravenously. However in small animal research intravenous administrations can be challenging, because partial paravenous injection is common due to the small calibre of the superficial tail veins and repeat administrations via tail veins can lead to tissue injury therefore limiting the total number of longitudinal scanning points. In this paper, the feasibility of using intra-peritoneal route of injection of ⁸F-NaF to study calcification in mice was studied by looking at the kinetic and

SUBMITTER: Gonzalez-Galofre ZN 

PROVIDER: S-EPMC7970902 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature