Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases.

ABSTRACT: Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recognition of DDIs between antiretrovirals and antimicrobials by three proprietary databases and evaluate their concordance. 114 items of antiretrovirals and antimicrobials from the National List of Essential Medicines of Thailand 2018 were used in the study. However, 21 items were not recognised by Micromedex, Drugs.com, and Liverpool HIV interactions. Only 93 items were available for the detection of potential DDIs by the three databases. Potential DDIs detected from the three databases included 292 pairs. L

SUBMITTER: Vivithanaporn P 

PROVIDER: S-EPMC7971054 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature