Metabolite profiling of endophytic Streptomyces spp. and its antiplasmodial potential.

ABSTRACT:

Background

Antiplasmodial drug discovery is significant especially from natural sources such as plant bacteria. This research aimed to determine antiplasmodial metabolites of Streptomyces spp. against Plasmodium falciparum 3D7 by using a metabolomics approach.

Methods

Streptomyces strains' growth curves, namely SUK 12 and SUK 48, were measured and P. falciparum 3D7 IC₅₀ values were calculated. Metabolomics analysis was conducted on both strains' mid-exponential and stationary phase extracts.

Results

The most successful antiplasmodial activity of SUK 12 and SUK 48 extracts shown to be at the stationary phase with IC₅₀ values of 0.8168 ng/mL and 0.1963 ng/mL, respectively. In contrast, the IC₅₀ value of

SUBMITTER: Ahmad SJ 

PROVIDER: S-EPMC7971094 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature