Pairwise Versus Multiple Global Network Alignment.

ABSTRACT: Biological network alignment (NA) aims to identify similar regions between molecular networks of different species. NA can be local or global. Just as the recent trend in the NA field, we also focus on global NA, which can be pairwise (PNA) and multiple (MNA). PNA produces aligned node pairs between two networks. MNA produces aligned node clusters between more than two networks. Recently, the focus has shifted from PNA to MNA, because MNA captures conserved regions between more networks than PNA (and MNA is thus hypothesized to yield higher-quality alignments), though at higher computational complexity. The issue is that, due to the different outputs of PNA and MNA, a PNA method is only compared to other PNA methods, and an MNA method is only compared to other MNA methods. Comparison of PN

SUBMITTER: Vijayan V 

PROVIDER: S-EPMC7971151 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature