A Patient-Specific Computational Framework for the Argus II Implant.

ABSTRACT:

Goal

Retinal prosthesis performance is limited by the variability of elicited phosphenes. The stimulating electrode's position with respect to retinal ganglion cells (RGCs) affects both perceptual threshold and phosphene shape. We created a modeling framework incorporating patient-specific anatomy and electrode location to investigate RGC activation and predict inter-electrode differences for one Argus II user.

Methods

We used ocular imaging to build a three-dimensional finite element model characterizing retinal morphology and implant placement. To predict the neural response to stimulation, we coupled electric fields with multi-compartment cable models of RGCs. We evaluated our model predictions by comparing them to patient-reported perceptual threshold measurements.

Re

SUBMITTER: Finn KE 

PROVIDER: S-EPMC7971167 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature