Metabolic phenotypes of standard and cold-stored platelets.

ABSTRACT:

Background

Conventional platelet (PLT) storage at room temperature under continuous agitation results in a limited shelf life (5 days) and an increased risk of bacterial contamination. However, both of these aspects can be ameliorated by cold storage. Preliminary work has suggested that PLTs can be cold stored for up to 3 weeks, while preserving their metabolic activity longer than in PLTs stored at room temperature. As such, in the present study, we hypothesized that the metabolic phenotypes of PLTs stored at 4°C for 3 weeks could be comparable to that of room temperature-stored PLTs at 22°C for 5 days.

Study design and methods

Metabolomics analyses were performed on nine apheresis PLT concentrates stored either at room temperature (22°C) for 5 days or refrigerated conditio

SUBMITTER: D'Alessandro A 

PROVIDER: S-EPMC7971209 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature