Prevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococci.

ABSTRACT: Background: The Tn916-Tn1545 family of Integrative Conjugative Elements (ICE) are mobile genetic elements (MGEs) that play a role in the spread of antibiotic resistance genes. The Tn916 harbors the tetracycline resistance gene tet(M) and it has been reported in various bacterial species. The increase in the levels of tetracycline resistance among oral streptococci is of great concern primarily due to the abundance of these species in the oral cavity and their ability to act as reservoirs for antibiotic resistance genes.Methods: In the current study, we screened 100 Norwegian clinical oral streptococcal isolates for the presence and diversity of the Tn916-Tn1545 family. In addition, we investigated the transferability the elements, and

SUBMITTER: Lunde TM 

PROVIDER: S-EPMC7971310 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature