Determination of Pain Phenotypes in Knee Osteoarthritis Using Latent Profile Analysis.

ABSTRACT:

Objective

To identify clinical phenotypes of knee osteoarthritis (OA) using measures from the following domains: 1) multimorbidity; 2) psychological distress; 3) pain sensitivity; and 4) knee impairment or pathology.

Design

Data were collected from 152 people with knee OA and from 31 pain-free individuals. In participants with knee OA, latent profile analysis (LPA) was applied to the following measures: normalized knee extensor strength, Functional Comorbidity Index (FCI), Pain Catastrophizing Scale (PCS), and local (knee) pressure pain threshold. Comparisons were performed between empirically derived phenotypes from the LPA and healthy older adults on these measures. Comparisons were also made between pheonotypes on pain intensity, functional measures, use of health care, a

SUBMITTER: Kittelson AJ 

PROVIDER: S-EPMC7971470 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature