Prediction of LncRNA-encoded small peptides in glioma and oligomer channel functional analysis using in silico approaches.

ABSTRACT: Glioma is a lethal malignant brain cancer, and many reports have shown that abnormalities in the behavior of water and ion channels play an important role in regulating tumor proliferation, migration, apoptosis, and differentiation. Recently, new studies have suggested that some long noncoding RNAs containing small open reading frames can encode small peptides and form oligomers for water or ion regulation. However, because the peptides are difficult to identify, their functional mechanisms are far from being clearly understood. In this study, we used bioinformatics methods to identify and evaluate lncRNAs, which may encode small transmembrane peptides in gliomas. Combining ab initio homology modeling, molecular dynamics simulations, and free energy calculations, we constructed a predictiv

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7971536 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature