Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila.

ABSTRACT: The winged insects of the order Diptera are colloquially named for their most recognizable phenotype: flight. These insects rely on flight for a number of important life history traits, such as dispersal, foraging, and courtship. Despite the importance of flight, relatively little is known about the genetic architecture of flight performance. Accordingly, we sought to uncover the genetic modifiers of flight using a measure of flies' reaction and response to an abrupt drop in a vertical flight column. We conducted a genome wide association study (GWAS) using 197 of the Drosophila Genetic Reference Panel (DGRP) lines, and identified a combination of additive and marginal variants, epistatic interactions, whole genes, and enrichment across interaction networks. Egfr, a highly pleiotropic deve

SUBMITTER: Spierer AN 

PROVIDER: S-EPMC7971549 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature