Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil.

ABSTRACT:

Background

While Zika virus (ZIKV) is now widely recognized as a teratogen, the frequency and full spectrum of adverse outcomes of congenital ZIKV infection remains incompletely understood.

Methods

Participants in the MERG cohort of pregnant women with rash, recruited from the surveillance system from December/2015-June/2017. Exposure definition was based on a combination of longitudinal data from molecular, serologic (IgM and IgG3) and plaque reduction neutralization tests for ZIKV. Children were evaluated by a team of clinical specialists and by transfontanelle ultrasound and were classified as having microcephaly and/or other signs/symptoms consistent with congenital Zika syndrome (CZS). Risks of adverse outcomes were quantified according to the relative evidence of a ZIK

SUBMITTER: Ximenes RAA 

PROVIDER: S-EPMC7971861 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature