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Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules.

ABSTRACT: Drosophila reproductive behaviors are directed by fruitless neurons. A reanalysis of genomic studies shows that genes encoding dpr and DIP immunoglobulin superfamily (IgSF) members are expressed in fru P1 neurons. We find that each fru P1 and dpr/DIP (fru P1 ∩ dpr/DIP) overlapping expression pattern is similar in both sexes, but there are dimorphisms in neuronal morphology and cell number. Behavioral studies of fru P1 ∩ dpr/DIP perturbation genotypes indicate that the mushroom body functions together with the lateral protocerebral complex to direct courtship behavior. A single-cell RNA-seq analysis of fru P1 neurons shows that many DIPs have high expression in a small set of neurons, whereas the dprs are often expressed in a larger set of neurons at intermediate levels, with a myriad of dpr/DIP expression combinations. Functionally, we find that perturbations of sex hierarchy genes and of DIP-ε change the sex-specific morphologies of fru P1 ∩ DIP-α neurons.

SUBMITTER: Brovero SG 

PROVIDER: S-EPMC7972454 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Investigation of <i>Drosophila fruitless</i> neurons that express Dpr/DIP cell adhesion molecules.

Brovero Savannah G SG   Fortier Julia C JC   Hu Hongru H   Lovejoy Pamela C PC   Newell Nicole R NR   Palmateer Colleen M CM   Tzeng Ruei-Ying RY   Lee Pei-Tseng PT   Zinn Kai K   Arbeitman Michelle N MN  

eLife 20210222

<i>Drosophila</i> reproductive behaviors are directed by <i>fruitless</i> neurons. A reanalysis of genomic studies shows that genes encoding <i>dpr</i> and <i>DIP</i> immunoglobulin superfamily (IgSF) members are expressed in <i>fru P1</i> neurons. We find that each <i>fru P1</i> and <i>dpr/DIP</i> (<i>fru P1</i> ∩ <i>dpr/DIP</i>) overlapping expression pattern is similar in both sexes, but there are dimorphisms in neuronal morphology and cell number. Behavioral studies of <i>fru P1</i> ∩ <i>dpr  ...[more]

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