Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein.

ABSTRACT: The mortality rates due to COVID-19 have been found disproportionate globally and are currently being researched. India mortality rate with a population of 1.3 billion people is relatively lowest to other countries with high infection rates. Genetic composition of circulating isolates continues to be a key determinant of virulence and pathogenesis. This study aimed to analyse the extent of divergence between genomes of Indian isolates (n = 2525 as compared to reference Wuhan-1 strain and isolates from countries showing higher fatality rates including France, Italy, Belgium, and the USA. The study also analyses the impact of key mutations on interactions with angiotensin converting enzyme 2 (ACE2) and panel of neutralizing monoclonal antibodies. Using 1,44,605 spike protein sequences, globa

SUBMITTER: Alai S 

PROVIDER: S-EPMC7972664 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature