Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility.

ABSTRACT:

Background and objective

The growing impact of the COVID-19 pandemic has heightened the urgency of identifying individuals most at risk of infection. Per- and poly-fluoroalkyl substances (PFASs) are manufactured fluorinated chemicals widely used in many industrial and household products. The objective of this case-control study was to assess the association between PFASs exposure and COVID-19 susceptibility and to elucidate the metabolic dysregulation associated with PFASs exposure in COVID-19 patients.

Methods

Total 160 subjects (80 COVID-19 patients and 80 symptom-free controls) were recruited from Shanxi and Shandong provinces, two regions heavily polluted by PFASs in China. Twelve common PFASs were quantified in both urine and serum. Urine metabolome profiling was perfor

SUBMITTER: Ji J 

PROVIDER: S-EPMC7972714 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature