Transcriptomic response of Saccharomyces cerevisiae to octanoic acid production.

ABSTRACT: The medium-chain fatty acid octanoic acid is an important platform compound widely used in industry. The microbial production from sugars in Saccharomyces cerevisiae is a promising alternative to current non-sustainable production methods, however, titers need to be further increased. To achieve this, it is essential to have in-depth knowledge about the cell physiology during octanoic acid production. To this end, we collected the first RNA-Seq data of an octanoic acid producer strain at three time points during fermentation. The strain produced higher levels of octanoic acid and increased levels of fatty acids of other chain lengths (C6-C18) but showed decreased growth compared to the reference. Furthermore, we show that the here analyzed transcriptomic response to internally produced oct

SUBMITTER: Baumann L 

PROVIDER: S-EPMC7972946 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature