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Construction and validation of a cerebral white matter hyperintensity probability map of older Koreans.


ABSTRACT:

Background and purpose

Although two white matter hyperintensity (WMH) probability maps of healthy older adults already exist, they have several limitations in representing the distribution of WMH in healthy older adults, especially Asian older adults. We constructed and validated a WMH probability map (WPM) of healthy older Koreans and examined the age-associated differences of WMH.

Methods

We constructed WPM using development dataset that consisted of high-resolution 3D fluid-attenuated inversion recovery images of 5 age groups (60-64 years, 65-69 years, 70-74 years, 75-79 years, and 80+ years). Each age group included 30 age-matched men and women each. We tested the validity of the WPM by comparing WMH ages estimated by the WPM and the chronological ages of 30 healthy controls, 30 hypertension patients, and 30 S patients.

Results

Older age groups showed a higher volume of WMH in both hemispheres (p < 0.001). About 90% of the WMH were periventricular in all age groups. With advancing age, the peak of the distance histogram from the ventricular wall of the periventricular WMH shifted away from the ventricular wall, while that of deep WMH shifted toward the ventricular wall. The estimated WMH ages were comparable to the chronological ages in the healthy controls, while being higher than the chronological ages in hypertension and stroke patients.

Conclusions

This WPM may serve as a standard atlas in research on WMH of older adults, especially Asians.

SUBMITTER: Kim JS 

PROVIDER: S-EPMC7972979 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Construction and validation of a cerebral white matter hyperintensity probability map of older Koreans.

Kim Jun Sung JS   Lee Subin S   Kim Grace Eun GE   Oh Dae Jong DJ   Moon Woori W   Bae Jong Bin JB   Han Ji Won JW   Byun Seonjeong S   Suh Seung Wan SW   Choi Yu Yong YY   Choi Kyu Yeong KY   Lee Kun Ho KH   Kim Jae Hyoung JH   Kim Ki Woong KW  

NeuroImage. Clinical 20210304


<h4>Background and purpose</h4>Although two white matter hyperintensity (WMH) probability maps of healthy older adults already exist, they have several limitations in representing the distribution of WMH in healthy older adults, especially Asian older adults. We constructed and validated a WMH probability map (WPM) of healthy older Koreans and examined the age-associated differences of WMH.<h4>Methods</h4>We constructed WPM using development dataset that consisted of high-resolution 3D fluid-att  ...[more]

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