Efficacy of linezolid on Treponema pallidum, the syphilis agent: A preclinical study.

ABSTRACT:

Background

Penicillin G, the current standard treatment for syphilis, has important drawbacks, but virtually no preclinical or clinical studies have been performed to identify viable alternatives. We tested, both in vitro and in vivo, three marketed antibiotics with adequate pharmacological properties to treat syphilis.

Methods

We used an in vitro culturing system of T. pallidum to perform drug susceptibility testing and applied quantitative PCR targeting the tp0574 gene to measure bacterial growth. To confirm in vivo efficacy, fifteen rabbits were infected intradermally with T. pallidum at eight sites each and randomly allocated to an experimental treatment (linezolid, moxifloxacin, clofazimine) or a control arm (benzathine penicillin G [BPG], untreated). The primary outcom

SUBMITTER: Haynes AM 

PROVIDER: S-EPMC7973135 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature