Modeling of Astrocyte Networks: Toward Realistic Topology and Dynamics.

ABSTRACT: Neuronal firing and neuron-to-neuron synaptic wiring are currently widely described as orchestrated by astrocytes-elaborately ramified glial cells tiling the cortical and hippocampal space into non-overlapping domains, each covering hundreds of individual dendrites and hundreds thousands synapses. A key component to astrocytic signaling is the dynamics of cytosolic Ca²⁺ which displays multiscale spatiotemporal patterns from short confined elemental Ca²⁺ events (puffs) to Ca²⁺ waves expanding through many cells. Here, we synthesize the current understanding of astrocyte morphology, coupling local synaptic activity to astrocytic Ca²⁺ in perisynaptic astrocytic processes and morphology-defined mechanisms of Ca²⁺ regulation in a distribute

SUBMITTER: Verisokin AY 

PROVIDER: S-EPMC7973220 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature