Increased Within-Network Functional Connectivity May Predict NEDA Status in Fingolimod-Treated MS Patients.

ABSTRACT: Only a few studies have evaluated the brain functional changes associated with disease-modifying therapies (DMTs) in multiple sclerosis (MS), though none used a composite measure of clinical and MRI outcomes to evaluate DMT-related brain functional connectivity (FC) measures predictive of short-term outcome. Therefore, we investigated the following: (1) baseline FC differences between patients who showed evidence of disease activity after a specific DMT and those who did not; (2) DMT-related effects on FC, and; (3) possible relationships between DMT-related FC changes and changes in performance. We used a previously analyzed dataset of 30 relapsing MS patients who underwent fingolimod treatment for 6 months and applied the "no evidence of disease activity" (NEDA-3) status as a clinical res

SUBMITTER: Piervincenzi C 

PROVIDER: S-EPMC7973271 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature