N-Glycomic Signature of Stage II Colorectal Cancer and Its Association With the Tumor Microenvironment.

ABSTRACT: The choice for adjuvant chemotherapy in stage II colorectal cancer is controversial as many patients are cured by surgery alone and it is difficult to identify patients with high risk of recurrence of the disease. There is a need for better stratification of this group of patients. Mass spectrometry imaging could identify patients at risk. We report here the N-glycosylation signatures of the different cell populations in a group of stage II colorectal cancer tissue samples. The cancer cells, compared with normal epithelial cells, have increased levels of sialylation and high-mannose glycans, as well as decreased levels of fucosylation and highly branched N-glycans. When looking at the interface between cancer and its microenvironment, it seems that the cancer N-glycosylation signature spre

SUBMITTER: Boyaval F 

PROVIDER: S-EPMC7973300 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature