Differential CircRNA Expression Profiles in PK-15 Cells Infected with Pseudorabies Virus Type II.

ABSTRACT: Circular RNAs (circRNAs) belong to a class of non-coding RNAs with diverse biological functions. However, little is known about their roles in case of pseudorabies virus (PrV) infection. Here, we analyzed the expression profile of host circRNAs from a virulent PrV type II strain DX (PrV-DX) infected and an attenuated gE/TK deficient (gE^-TK^-PrV) strain of PrV infected PK-15 cells. CircRNAs were identified by find_circ and analyzed with DESeq 2. Compared with the mock cells, 449 differentially expressed (DE) circRNAs (233 down-regulated and 216 up-regulated) from PrV-DX infected and 578 DE circRNAs (331 down-regulated and 247 up-regulated) from gE^-TK^- PrV infected PK-15 cells were identified. In addition, 459 DE circRNAs (164 down-regulated and 295

SUBMITTER: Li H 

PROVIDER: S-EPMC7973350 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature