A bottom-up approach to creating an ontology for medication indications.

ABSTRACT:

Objectives

The study sought to learn if it were possible to develop an ontology that would allow the Food and Drug Administration approved indications to be expressed in a manner computable and comparable to what is expressed in an electronic health record.

Materials and methods

A random sample of 1177 of the 3000+ extant, distinct medical products (identified by unique new drug application numbers) was selected for investigation. Close manual examination of the indication portion of the labels for these drugs led to the development of a formal model of indications.

Results

The model represents each narrative indication as a disjunct of conjuncts of assertions about an individual. A desirable attribute is that each assertion about an individual should be testable with

SUBMITTER: Nelson SJ 

PROVIDER: S-EPMC7973454 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature