Input-selective adenosine A₁ receptor-mediated synaptic depression of excitatory transmission in dorsal striatum.

ABSTRACT: The medial (DMS) and lateral (DLS) dorsal striatum differentially drive goal-directed and habitual/compulsive behaviors, respectively, and are implicated in a variety of neuropsychiatric disorders. These subregions receive distinct inputs from cortical and thalamic regions which uniquely determine dorsal striatal activity and function. Adenosine A₁ receptors (A1Rs) are prolific within striatum and regulate excitatory glutamate transmission. Thus, A1Rs may have regionally-specific effects on neuroadaptive processes which may ultimately influence striatally-mediated behaviors. The occurrence of A1R-driven plasticity at specific excitatory inputs to dorsal striatum is currently unknown. To better understand how A1Rs may influence these behaviors, we first sought to understand how A

SUBMITTER: Fritz BM 

PROVIDER: S-EPMC7973535 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature