Real time observation of the interaction between aluminium salts and sweat under microfluidic conditions.

ABSTRACT: Aluminium salts such as aluminium chlorohydrate (ACH) are the active ingredients of antiperspirant products. Their mechanism of action involves a temporary and superficial plugging of eccrine sweat pores at the skin surface. We developed a microfluidic system that allows the real time observation of the interactions between sweat and ACH in conditions mimicking physiological sweat flow and pore dimensions. Using artificial sweat containing bovine serum albumin as a model protein, we performed experiments under flowing conditions to demonstrate that pore clogging results from the aggregation of proteins by aluminium polycations at specific location in the sweat pore. Combining microfluidic experiments, confocal microscopy and numerical models helps to better understand the physical chemistr

SUBMITTER: Sakhawoth Y 

PROVIDER: S-EPMC7973555 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature