Association of Olfactory Training With Neural Connectivity in Adults With Postviral Olfactory Dysfunction.

ABSTRACT:

Importance

Viral upper respiratory tract infections are a major cause of olfactory loss. Olfactory training (OT) is a promising intervention for smell restoration; however, a mechanistic understanding of the changes in neural plasticity induced by OT is absent.

Objective

To evaluate functional brain connectivity in adults with postviral olfactory dysfunction (PVOD) before and after OT using resting-state functional magnetic resonance imaging.

Design, setting, and participants

This prospective cohort study, conducted from September 1, 2017, to November 30, 2019, recruited adults with clinically diagnosed or self-reported PVOD of 3 months or longer. Baseline olfaction was measured using the University of Pennsylvania Smell Identification Test (UPSIT) and the Sniffin' St

SUBMITTER: Jiramongkolchai P 

PROVIDER: S-EPMC7974830 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature